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KMID : 0620920090410040253
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Experimental & Molecular Medicine
2009 Volume.41 No. 4 p.253 ~ p.258
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Higher mitochondrial DNA copy number is associated with lower prevalence of microalbuminuria
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Lee Jung-Eun
Park Han-Soo
Ju Young-Seok
Kwak Min-Hye
Kim Jong-Il
Oh Ha-Young
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Abstract
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It has been suggested that mitochondrial dysfunction contributes to the initiation and development of atherosclerosis and cardiovascular disease. We examined the association between mitochondrial DNA (mtDNA) copy number and microalbuminuria in a cross-sectional community-based study. We measured peripheral blood mtDNA copy number in 694 adults without chronic kidney disease by a real-time PCR method. The overall prevalence of microalbuminuria (defined as an albumin creatinine ratio of 30 to 299 mg/g) was 4.5%. The prevalence of microalbuminuria decreased progressively from the lower to the upper quartiles of mtDNA copy number (6.9%, 5.7%, 2.9%, and 2.3% in quartiles 1, 2, 3, and 4, respectively, P = 0.017 for trend). Multiple logistic regression models showed that the quartile of mtDNA copy number was independently associated with the prevalence of microalbuminuria (P = 0.01 for trend). Compared with the lowest quartile, the highest quartile had an odds ratio of 0.22 for microalbuminuria (95% confidence interval, 0.05 to 0.87; P = 0.03). Higher mtDNA copy number was associated with the lower prevalence of microalbuminuria in a community-based population.
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KEYWORD
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albuminuria, cardiovascular diseases, DNA, mitochondrial, mitochondria, oxidative phosphorylation
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